Both the senescence of cancer cells and the maintenance of cancer stem cells seem to be
mutually exclusive because senescence is considered a physiological mechanism that …

Background Cellular senescence is a common biological process with a well-established
link to cancer. However, the impact of cellular senescence on tumor progression remains …

In a recent paper in Nature, Park et al. propose a mechanism through which intestinal
dysbiosis compromises the efficacy of immunotherapy targeting the PD-L1/PD− 1 …

Cellular immortalization is a complex process that requires multiple genetic alterations to
overcome restricting barriers, including senescence. Not surprisingly, many of these …

Abstract Background/Aim: Thyroid carcinoma (THCA) is a cancer of the endocrine system
that most commonly affects women. Aging-associated genes play a critical role in various …

Mitochondrial dysfunction is one of the main factors that affects aging progression and many
age-related diseases. Accumulation of dysfunctional mitochondria can be driven by …

Lentivirus containing simian virus 40 large T antigen (SV40T) is routinely used to induce cell
immortalization. However, the roles of viral integration itself in this progress is still …

Introduction We aimed to highlight the effects of senotherapy on the prevention and
treatment of cancer in older individuals. The aim of senotherapy is to eliminate senescent …

PITX1, also known as the pituitary homeobox 1 gene, has emerged as a key regulator in
animal growth and development, attracting significant research attention. Recent …

Epigenetic modifications including DNA methylation, histone modifications, chromatin
remodeling, and RNA modifications complicate gene regulation and heredity and profoundly …