The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global health concern. Three years …

Current studies have shown that gut microbiota may be closely related to the severity of
coronavirus disease 2019 (COVID-19) by regulating the host immune response. Qing-Fei …

Purinergic signaling modulates immune function and is involved in the
immunopathogenesis of several viral infections. This study aimed to investigate alterations …

A long-shared evolutionary history is congruent with the multiple roles played by purinergic
signaling in viral infection, replication and host responses that can assist or hinder viral …

Background Evidence supports the observational associations of human blood metabolites
with the risk of severe COVID‐19. However, little is known about the potential pathological …

Observational studies have reported high comorbidity between obesity and severe COVID-
19. The aim of this study is to explore whether genetic factors are involved in the co …

Background In this phase 2 randomised placebo-controlled clinical trial in patients with
COVID-19, we hypothesised that blocking mineralocorticoid receptors using a combination …

Background Information on the microbiome's human pathways and active members that can
affect SARS-CoV-2 susceptibility and pathogenesis in the salivary proteome is very scarce …

Substantial efforts have been made to understand the immune response during severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, in order to identify and …

Objective SARS-CoV-2 infection has been shown to result in increased circulating levels of
adenosine triphosphate and adenosine diphosphate and decreased levels of adenosine …