Navigating the intricate landscape of the tumor microenvironment (TME) unveils a pivotal
arena for cancer therapeutics, where cytokines and soluble mediators emerge as double …

Inflammatory bowel disease (IBD) is a lifelong inflammatory immune mediated disorder,
encompassing Crohn's disease (CD) and ulcerative colitis (UC); however, the cause and …

Precision medicine and personalized medicine are two approaches to healthcare that aim to
tailor medical treatments and interventions to individual patients. These approaches are …

Colorectal cancer (CRC) is a complex disease characterized by genetic and epigenetic
alterations, playing a crucial role in its development and progression. This review aims to …

Members of the CXC motif chemokine receptor (CXCR) superfamily play central roles in
initiating the innate immune response in mammalian cells by orchestrating selective cell …

Over the past few decades, significant strides have been made in understanding the pivotal
roles that chemokine networks play in tumor biology. These networks, comprising …

The interactions between vascular cells, especially endothelial cells, and macrophages play
a pivotal role in maintaining the subtle balance of vascular biology, which is crucial for …

Diabetes mellitus (DM) is the most common metabolic disease in humans, and its
prevalence is increasing worldwide in parallel with the obesity pandemic. A lack of insulin or …

Epigenetic modifications, characterized by changes in gene expression without altering the
DNA sequence, play a crucial role in the development and progression of cancer by …

The ever-increasing availability of genome sequencing data has revealed a substantial
number of uncharacterized genes without known functions across various organisms. The …