Aging-induced alternations of vasculature structures, phenotypes, and functions are key in
the occurrence and development of vascular aging-related diseases. Multiple molecular and …

Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases
include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and …

The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …

Background: Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for
the pathogenesis of a variety of vascular diseases during the early stage. Recent studies …

Evidence from epidemiological studies has demonstrated that the incidence and mortality of
cardiovascular diseases (CVDs) increase year by year, which pose a great threat on social …

Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the
intramural accumulation of blood, are a family of catastrophic disorders causing major …

The medial layer of the arterial wall is composed mainly of vascular smooth muscle cells
(VSMCs). Under physiological conditions, VSMCs assume a contractile phenotype, and their …

Background: Metabolic disorder increases the risk of abdominal aortic aneurysm (AAA). NRs
(nuclear receptors) have been increasingly recognized as important regulators of cell …

Vascular smooth muscle cell (VSMC) proliferation and migration are critical events that
contribute to the pathogenesis of vascular diseases such as atherosclerosis, restenosis, and …

Background The dynamics of the cellular glycolysis pathway underpin cellular function and
dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies …