DNA methylation methods: Global DNA methylation and methylomic analyses
S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …
significant involvement for numerous biological processes in health and disease. The …
Analysing and interpreting DNA methylation data
C Bock - Nature Reviews Genetics, 2012 - nature.com
DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …
of biological processes and diseases. The technology is now available for studying DNA …
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …
provided a user-friendly platform to profile DNA methylation in human samples. However …
Epigenetic signatures of cigarette smoking
Background—DNA methylation leaves a long-term signature of smoking exposure and is
one potential mechanism by which tobacco exposure predisposes to adverse health …
one potential mechanism by which tobacco exposure predisposes to adverse health …
[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi
The minfi package is widely used for analyzing Illumina DNA methylation array data. Here
we describe modifications to the minfi package required to support the …
we describe modifications to the minfi package required to support the …
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
TJ Sarkar, M Quarta, S Mukherjee, A Colville… - Nature …, 2020 - nature.com
Aging is characterized by a gradual loss of function occurring at the molecular, cellular,
tissue and organismal levels. At the chromatin level, aging associates with progressive …
tissue and organismal levels. At the chromatin level, aging associates with progressive …
A deep learning framework with an embedded-based feature selection approach for the early detection of the Alzheimer's disease
N Mahendran, DRV PM - Computers in Biology and Medicine, 2022 - Elsevier
Ageing is associated with various ailments including Alzheimer's disease (AD), which is a
progressive form of dementia. AD symptoms develop over a period of years and …
progressive form of dementia. AD symptoms develop over a period of years and …
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
Abstract Motivation: The recently released Infinium HumanMethylation450 array (the
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
Systematic identification of genetic influences on methylation across the human life course
Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …