The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

KKW To, S Sridhar, KHY Chiu, DLL Hung… - Emerging microbes & …, 2021 - Taylor & Francis
Without modern medical management and vaccines, the severity of the Coronavirus
Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) …

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration

L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

R Martínez-Mármol, R Giordano-Santini, E Kaulich… - Science …, 2023 - science.org
Numerous viruses use specialized surface molecules called fusogens to enter host cells.
Many of these viruses, including the severe acute respiratory syndrome coronavirus 2 …

Cognitive impact of COVID-19: looking beyond the short term

S Miners, PG Kehoe, S Love - Alzheimer's research & therapy, 2020 - Springer
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments

SJ Yong - Infectious diseases, 2021 - Taylor & Francis
Long COVID or post-COVID-19 syndrome first gained widespread recognition among social
support groups and later in scientific and medical communities. This illness is poorly …

The neurological manifestations of post-acute sequelae of SARS-CoV-2 infection

N Moghimi, M Di Napoli, J Biller, JE Siegler… - Current Neurology and …, 2021 - Springer
Abstract Purpose of Review Coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health challenge. This …

Persistent brainstem dysfunction in long-COVID: a hypothesis

SJ Yong - ACS chemical neuroscience, 2021 - ACS Publications
Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial
disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal …

[PDF][PDF] ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response

C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen… - Cell stem cell, 2021 - cell.com
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …

A human three-dimensional neural-perivascular 'assembloid'promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology

L Wang, D Sievert, AE Clark, S Lee, H Federman… - Nature medicine, 2021 - nature.com
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-
2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are …