Facing up to the global challenges of ageing

L Partridge, J Deelen, PE Slagboom - Nature, 2018 - nature.com
Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Biological Versus Chronological Aging: JACC Focus Seminar

MR Hamczyk, RM Nevado, A Barettino, V Fuster… - Journal of the American …, 2020 - jacc.org
Aging is the main risk factor for vascular disease and ensuing cardiovascular and
cerebrovascular events, the leading causes of death worldwide. In a progressively aging …

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

R Martins, GJ Lithgow, W Link - Aging cell, 2016 - Wiley Online Library
Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

Ageing, neurodegeneration and brain rejuvenation

T Wyss-Coray - Nature, 2016 - nature.com
Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

A synopsis on aging—Theories, mechanisms and future prospects

JP da Costa, R Vitorino, GM Silva, C Vogel… - Ageing research …, 2016 - Elsevier
Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women

LO Lee, P James, ES Zevon, ES Kim… - Proceedings of the …, 2019 - National Acad Sciences
Most research on exceptional longevity has investigated biomedical factors associated with
survival, but recent work suggests nonbiological factors are also important. Thus, we tested …

Biodemography of human ageing

JW Vaupel - Nature, 2010 - nature.com
Human senescence has been delayed by a decade. This finding, documented in 1994 and
bolstered since, is a fundamental discovery about the biology of human ageing, and one …

[图书][B] Behavioral genetics

R Plomin - 2008 - books.google.com
Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

C Franceschi, M Capri, D Monti, S Giunta… - Mechanisms of ageing …, 2007 - Elsevier
A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

Genetics of healthy aging and longevity

AR Brooks-Wilson - Human genetics, 2013 - Springer
Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …