[HTML][HTML] Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer
DM Borràs, S Verbandt, M Ausserhofer, G Sturm, J Lim… - Cell Discovery, 2023 - nature.com
CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …
Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexities
S Ahuja, S Zaheer - Cell Biology International, 2024 - Wiley Online Library
Physiological embryogenesis and adult tissue homeostasis are regulated by transforming
growth factor‐β (TGF‐β), an evolutionarily conserved family of secreted polypeptide factors …
growth factor‐β (TGF‐β), an evolutionarily conserved family of secreted polypeptide factors …
[HTML][HTML] A characterized ethanol extract of Rosa rugosa inhibits hepatic stellate cell activation through elevating Hint1 and subsequent upregulation of Smad7
G Shu, X Lei, Y Lei, T Zhang, H Sun, C Wang… - Journal of Functional …, 2023 - Elsevier
Our study aimed to explore effects of a characterized ethanol extract of Rosa rugosa (ERS)
on hepatic stellate cells (HSCs) activation and mouse liver fibrosis and their molecular …
on hepatic stellate cells (HSCs) activation and mouse liver fibrosis and their molecular …
Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl 4-induced liver …
G Shu, X Lei, G Li, T Zhang, C Wang, A Song, H Yu… - Food & Function, 2023 - pubs.rsc.org
Ergothioneine (EGT) is a bioactive compound derived from certain edible mushrooms. The
activation of hepatic stellate cells (HSCs) is critically involved in the etiology of liver fibrosis …
activation of hepatic stellate cells (HSCs) is critically involved in the etiology of liver fibrosis …
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
S Liang, R Zheng, B Zuo, J Li, Y Wang, Y Han… - Cellular & Molecular …, 2024 - nature.com
Despite the tremendous progress of chimeric antigen receptor T (CAR-T) cell therapy in
hematological malignancies, their application in solid tumors has been limited largely due to …
hematological malignancies, their application in solid tumors has been limited largely due to …
[HTML][HTML] Novel genome-wide DNA methylation profiling reveals distinct epigenetic landscape, prognostic model and cellular composition of early-stage lung …
J Gan, M Huang, W Wang, G Fu, M Hu, H Zhong… - Journal of Translational …, 2024 - Springer
Background Lung adenocarcinoma (LUAD) has been a leading cause of cancer-related
mortality worldwide. Early intervention can significantly improve prognosis. DNA methylation …
mortality worldwide. Early intervention can significantly improve prognosis. DNA methylation …
Systematical identification of key genes and regulatory genetic variants associated with prognosis of esophageal squamous cell carcinoma
L Gu, X Yue, S Niu, J Ma, S Liu, M Pan… - Molecular …, 2024 - Wiley Online Library
Esophageal squamous cell carcinoma (ESCC) stands as a highly lethal malignancy
characterized by pronounced recurrence and metastasis, resulting in a bleak 5‐year survival …
characterized by pronounced recurrence and metastasis, resulting in a bleak 5‐year survival …
An Ensemble Docking Approach for Analyzing and Designing Aptamer Heterodimers Targeting VEGF165
YJ Go, M Kalathingal, YM Rhee - International Journal of Molecular …, 2024 - mdpi.com
Vascular endothelial growth factor 165 (VEGF165) is a prominent isoform of the VEGF-A
protein that plays a crucial role in various angiogenesis-related diseases. It is homodimeric …
protein that plays a crucial role in various angiogenesis-related diseases. It is homodimeric …
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7
T Kitagawa, T Matsumoto, T Ohta, T Yoshida… - Journal of Natural …, 2024 - Springer
The Wnt/β-catenin signaling pathway plays important roles in several cancer cells, including
cell proliferation and development. We previously succeeded in synthesizing a small …
cell proliferation and development. We previously succeeded in synthesizing a small …
[HTML][HTML] Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation
Q Zhang, W Zhao, Z Sun, X Dong, L Zhu… - Frigid Zone …, 2024 - degruyter.com
Background Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by
a progressive decline in liver function, leading to disruptions in liver integrity and metabolic …
a progressive decline in liver function, leading to disruptions in liver integrity and metabolic …