The role of adult hippocampal neurogenesis in brain health and disease
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain
Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …
mammalian brain into adulthood. Adult neurogenesis has been best described in the …
Adult neurogenesis in the hippocampus: from stem cells to behavior
The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …
during adulthood. These adult-born neurons become functionally active and are thought to …
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease
L Jia, J Piña-Crespo, Y Li - Molecular brain, 2019 - Springer
Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
Roles for retrotransposon insertions in human disease
DC Hancks, HH Kazazian - Mobile DNA, 2016 - Springer
Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
A NeuroD1 AAV-based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion
Adult mammalian brains have largely lost neuroregeneration capability except for a few
niches. Previous studies have converted glial cells into neurons, but the total number of …
niches. Previous studies have converted glial cells into neurons, but the total number of …
Restricting retrotransposons: a review
JL Goodier - Mobile DNA, 2016 - Springer
Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model
Loss of neurons after brain injury and in neurodegenerative disease is often accompanied
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …
Regulation and function of adult neurogenesis: from genes to cognition
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …
and potential impact on cognition but also to its localized vertical integration of different …
Neurogenesis in the embryonic and adult brain: same regulators, different roles
N Urbán, F Guillemot - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …