Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
Epigenetic modifications in stress response genes associated with childhood trauma
Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease
M Tsalenchuk, SM Gentleman, SJ Marzi - npj Parkinson's Disease, 2023 - nature.com
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …
complex risk structure thought to be influenced by interactions between genetic variants and …
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …
Refining epigenetic prediction of chronological and biological age
Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
RF Hillary, DL McCartney, HM Smith, E Bernabeu… - PLoS …, 2023 - journals.plos.org
Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer's disease
DNA methylation differences in Alzheimer's disease (AD) have been reported. Here, we
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts
E Fraszczyk, AMW Spijkerman, Y Zhang, S Brandmaier… - Diabetologia, 2022 - Springer
Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing
prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic …
prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic …
Retrofitting existing buildings to improve energy performance
Energy-efficient retrofits embrace enhancement of the building envelope through climate
control strategies, employment of building-integrated renewable energy technologies, and …
control strategies, employment of building-integrated renewable energy technologies, and …