The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Advanced age is the largest risk factor for late‐onset Alzheimer's disease (LOAD), a disease
in which susceptibility correlates to almost all hallmarks of aging. Shared genetic signatures …

To understand the genetic basis and selective forces acting on longevity, it is useful to
examine lifespan variation among closely related species, or ecologically diverse isolates of …

Biological aging is a complex process involving multiple biological processes. These can be
understood theoretically though considering them as individual networks—eg, epigenetic …

Mutations of a single gene can lead to a major increase in longevity in organisms ranging
from yeast and worms to insects and mammals. Discovering these mutations (sometimes …

A major goal of aging research is identifying genetic targets that could be used to slow or
reverse aging–changes in the body and extend limits of human lifespan. However, majority …

Longevity is a hallmark of successful ageing and a complex trait with a significant genetic
component. In this study, 43 single nucleotide polymorphisms (SNPs) were chosen from the …