Hallmarks of T cell aging
M Mittelbrunn, G Kroemer - Nature immunology, 2021 - nature.com
The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …
[HTML][HTML] Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives
A Vaiserman, D Krasnienkov - Frontiers in Genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
[HTML][HTML] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
[HTML][HTML] DNA methylation-based estimator of telomere length
Telomere length (TL) is associated with several aging-related diseases. Here, we present a
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …
An integrative study of five biological clocks in somatic and mental health
Biological clocks have been developed at different molecular levels and were found to be
more advanced in the presence of somatic illness and mental disorders. However, it is …
more advanced in the presence of somatic illness and mental disorders. However, it is …
Accelerating research on biological aging and mental health: Current challenges and future directions
Aging is associated with complex biological changes that can be accelerated, slowed, or
even temporarily reversed by biological and non-biological factors. This article focuses on …
even temporarily reversed by biological and non-biological factors. This article focuses on …
[HTML][HTML] GWAS of epigenetic aging rates in blood reveals a critical role for TERT
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan,
but its underlying molecular mechanisms are unknown. In this genome-wide association …
but its underlying molecular mechanisms are unknown. In this genome-wide association …
Accelerated hippocampal biological aging in bipolar disorder
Objectives Evidence suggests accelerated aging mechanisms in bipolar disorder (BD),
including DNA methylation (DNAm) aging in blood. However, it is unknown whether such …
including DNA methylation (DNAm) aging in blood. However, it is unknown whether such …
DNA methylation age—environmental influences, health impacts, and its role in environmental epidemiology
R Dhingra, JC Nwanaji-Enwerem, M Samet… - Current environmental …, 2018 - Springer
Purpose of Review DNA methylation-based aging biomarkers are valuable tools for
evaluating the aging process from a molecular perspective. These epigenetic aging …
evaluating the aging process from a molecular perspective. These epigenetic aging …