[HTML][HTML] Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Antiaging diets: Separating fact from fiction

MB Lee, CM Hill, A Bitto, M Kaeberlein - Science, 2021 - science.org
BACKGROUND Reduced caloric intake without malnutrition is the oldest known life span–
extending intervention. Laboratory studies throughout the 20th century established and …

[HTML][HTML] DeepMAge: a methylation aging clock developed with deep learning

F Galkin, P Mamoshina, K Kochetov… - Aging and …, 2021 - ncbi.nlm.nih.gov
DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …

Human age reversal: Fact or fiction?

AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

[HTML][HTML] Revisiting the hallmarks of aging to identify markers of biological age

F Guerville, P De Souto Barreto, I Ader… - The Journal of …, 2020 - Springer
The Geroscience aims at a better understanding of the biological processes of aging, to
prevent and/or delay the onset of chronic diseases and disability as well as to reduce the …

[HTML][HTML] Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections

A Zhavoronkov - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
The recently identified SARS-CoV-2 betacoronavirus responsible for the COVID-19
pandemic has uncovered the age-associated vulnerability in the burden of disease and put …

[HTML][HTML] How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span

AM Galow, S Peleg - Cells, 2022 - mdpi.com
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

[HTML][HTML] ARDD 2020: from aging mechanisms to interventions

GV Mkrtchyan, K Abdelmohsen, P Andreux… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …

[HTML][HTML] Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related …

A Urban, D Sidorenko, D Zagirova, E Kozlova… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Aging is a complex and multifactorial process that increases the risk of various age-related
diseases and there are many aging clocks that can accurately predict chronological age …

Artificial intelligence in longevity medicine

A Zhavoronkov, E Bischof, KF Lee - Nature Aging, 2021 - nature.com
Recent advances in deep learning enabled the development of AI systems that outperform
humans in many tasks and have started to empower scientists and physicians with new …