Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with
physiological decline and stem cell exhaustion. However, whether the circadian machinery …

Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …

Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia, and
increases the risk of many aging-related metabolic diseases. Here, we report phenotypic …

Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …