Tryptophan metabolism in inflammaging: from biomarker to therapeutic target
FJH Sorgdrager, PJW Naudé, IP Kema… - Frontiers in …, 2019 - frontiersin.org
Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …
Brain age and other bodily 'ages': implications for neuropsychiatry
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …
The Aging Biomarker Consortium represents a new era for aging research in China
The global population of older peo-ple is growing at an unprecedented rate, with the number
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …
Molecular and physiological manifestations and measurement of aging in humans
Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …
in tissues and organs. This reduction manifests as a decreased physiological reserve in …
The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
AA Johnson, A Stolzing - Aging cell, 2019 - Wiley Online Library
An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
[HTML][HTML] Deep biomarkers of human aging: application of deep neural networks to biomarker development
One of the major impediments in human aging research is the absence of a comprehensive
and actionable set of biomarkers that may be targeted and measured to track the …
and actionable set of biomarkers that may be targeted and measured to track the …
[HTML][HTML] 60 years of healthy aging: on definitions, biomarkers, scores and challenges
LC Behr, A Simm, A Kluttig, A Grosskopf - Ageing Research Reviews, 2023 - Elsevier
ABSTRACT BACKGROUND AND OBJECTIVE As the proportion of aging people in our
population increases steadily, global strategies accompanied by extensive research are …
population increases steadily, global strategies accompanied by extensive research are …
Biomarkers of aging: from function to molecular biology
Aging is a major risk factor for most chronic diseases and functional impairments. Within a
homogeneous age sample there is a considerable variation in the extent of disease and …
homogeneous age sample there is a considerable variation in the extent of disease and …
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …
function and chronic disease and have led to the development of geroscience-guided …
Small nucleoli are a cellular hallmark of longevity
Animal lifespan is regulated by conserved metabolic signalling pathways and specific
transcription factors, but whether these pathways affect common downstream mechanisms …
transcription factors, but whether these pathways affect common downstream mechanisms …