Immunosurveillance in clinical cancer management

G Kroemer, TA Chan, AMM Eggermont… - CA: A Cancer Journal …, 2024 - Wiley Online Library
The progression of cancer involves a critical step in which malignant cells escape from
control by the immune system. Antineoplastic agents are particularly efficient when they …

Targeting immunogenic cell stress and death for cancer therapy

L Galluzzi, E Guilbaud, D Schmidt, G Kroemer… - Nature Reviews Drug …, 2024 - nature.com
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …

Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells

P Liu, L Zhao, L Zitvogel, O Kepp… - Immunological …, 2024 - Wiley Online Library
The search for immunostimulatory drugs applicable to cancer immunotherapy may profit
from target‐agnostic methods in which agents are screened for their functional impact on …

Melanoma and microbiota: Current understanding and future directions

B Routy, T Jackson, L Mählmann, CK Baumgartner… - Cancer Cell, 2024 - cell.com
Over the last decade, the composition of the gut microbiota has been found to correlate with
the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points …

Lifestyle and host determinants of antitumor immunity and cancer health disparities

A Swaby, A Atallah, O Varol, A Cristea, DF Quail - Trends in Cancer, 2023 - cell.com
Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …

Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell

X Zhu, K Li, G Liu, R Wu, Y Zhang, S Wang, M Xu… - Gut …, 2023 - Taylor & Francis
Recent studies have demonstrated that the antitumor immunity of immune cells can be
modulated by gut microbiota and their metabolites. However, the underlying mechanisms …

Trial watch: beta-blockers in cancer therapy

K Carnet Le Provost, O Kepp, G Kroemer, L Bezu - 2023 - Taylor & Francis
Compelling evidence supports the hypothesis that stress negatively impacts cancer
development and prognosis. Irrespective of its physical, biological or psychological source …

[HTML][HTML] Impact of microbiota on breast cancer hormone therapy

S Terrisse, L Zitvogel, G Kroemer - Cell Stress, 2023 - ncbi.nlm.nih.gov
Recent observations indicate that the pathogenesis and prognosis of hormone-receptor
breast cancer is not only dictated by the properties of the malignant cells but also by immune …

Prevention and treatment of cancers by tumor antigen-expressing Staphylococcus epidermidis

O Kepp, L Zitvogel, G Kroemer - Oncoimmunology, 2023 - Taylor & Francis
In a recent paper in Science, Chen et al. reported the genetic engineering of S. epidermidis
expressing tumor cross-reactive antigens that trigger T cell responses and exhibit anticancer …

[HTML][HTML] Social isolation activates dormant mammary tumors, and modifies inflammatory and mitochondrial metabolic pathways in the rat mammary gland

FO Andrade, L Jin, R Clarke, I Wood, MA Dutton… - Cells, 2023 - mdpi.com
Although multifactorial in origin, one of the most impactful consequences of social isolation
is an increase in breast cancer mortality. How this happens is unknown, but many studies …