Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy

M Hashemi, MS Moosavi, HM Abed, M Dehghani… - Pharmacological …, 2022 - Elsevier
Initiation and development of cancer depend on multiple factors that mutations in genes and
epigenetic level can be considered as important drivers. Epigenetic factors include a large …

MGMT and whole-genome DNA methylation impacts on diagnosis, prognosis and therapy of glioblastoma multiforme

R Della Monica, M Cuomo, M Buonaiuto… - International Journal of …, 2022 - mdpi.com
Epigenetic changes in DNA methylation contribute to the development of many diseases,
including cancer. In glioblastoma multiforme, the most prevalent primary brain cancer and …

Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics

V Fedyuk, N Erez, N Furth, O Beresh… - Nature …, 2023 - nature.com
The analysis of cell-free DNA (cfDNA) in plasma provides information on pathological
processes in the body. Blood cfDNA is in the form of nucleosomes, which maintain their …

Unveiling the mechanisms and challenges of cancer drug resistance

SU Khan, K Fatima, S Aisha, F Malik - Cell Communication and Signaling, 2024 - Springer
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

AA Bhat, G Gupta, R Dahiya, R Thapa, A Gahtori… - Non-coding RNA …, 2024 - Elsevier
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …

The potential of DNA methylation as a biomarker for obesity and smoking

A Heikkinen, S Bollepalli… - Journal of internal …, 2022 - Wiley Online Library
DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance

MJ Al-Imam, UAR Hussein, FF Sead, AMA Faqri… - DNA repair, 2023 - Elsevier
DNA methylation is one of the main epigenetic mechanisms in cancer development and
progression. Aberrant DNA methylation of CpG islands within promoter regions contributes …

Neurodegenerative movement disorders: An epigenetics perspective and promise for the future

M Murthy, YY Cheng, JL Holton… - Neuropathology and …, 2021 - Wiley Online Library
Neurodegenerative movement disorders (NMDs) are age‐dependent disorders that are
characterised by the degeneration and loss of neurons, typically accompanied by …

Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets

N El Omari, M Bakha, H Imtara… - … Science and Pollution …, 2021 - Springer
It has recently been proven that epigenetic dysregulation is importantly involved in cell
transformation and therefore induces cancerous diseases. The development of molecules …

Cell-of-origin targeted drug repurposing for triple-negative and inflammatory breast carcinoma with HDAC and HSP90 inhibitors combined with niclosamide

U Bhattacharya, M Kamran, M Manai, M Cristofanilli… - Cancers, 2023 - mdpi.com
Simple Summary The human body is composed of hundreds of different normal cell types.
Some of the important and unique features of these normal cell types are inherited by the …