Cell− cell communication, as a basic feature of multicellular organisms, is crucial for
maintaining the biological functions and microenvironmental homeostasis of cells, organs …

Aging is a natural process associated with declined organ function and higher susceptibility
to developing chronic diseases. A systemic single‐cell type‐based study provides a unique …

During aging, animals experience a decline in proteostasis activity, including loss of stress-
response activation, culminating in the accumulation of misfolded proteins and toxic …

Abstract The 2023 Nucleic Acids Research Database Issue contains 178 papers ranging
across biology and related fields. There are 90 papers reporting on new databases and 82 …

Aging entails gradual functional decline influenced by interconnected factors. Multiple
hallmarks proposed as common and conserved underlying denominators of aging on the …

Osteoporosis is a chronic inflammatory disease that severely affects quality of life. Cornus
officinalis is a Chinese herbal medicine with various bioactive ingredients, among which …

Gene regulatory networks (GRNs) are interpretable graph models encompassing the
regulatory interactions between transcription factors (TFs) and their downstream target …

Chromatin accessibility profiles at single cell resolution can reveal cell type-specific
regulatory programs, help dissect highly specialized cell functions and trace cell origin and …

Age-associated changes in DNA methylation have been characterized across various
animals, but not yet in amphibians, which are of particular interest because they include …

Aging is accompanied by a decreased DNA repair capacity, which might contribute to age‐
associated functional decline in multiple tissues. Disruption in hormone signaling …