Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Abstract Theory predicts that biological processes of aging may contribute to poor mental
health in late life. To test this hypothesis, we evaluated prospective associations between …

Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

Summary Apolipoprotein E4 (APOEε4) is the major allelic risk factor for late-onset sporadic
Alzheimer's disease (sAD). Inflammation is increasingly considered as critical in sAD …

Background and Objectives DNA methylation algorithms are increasingly used to estimate
biological aging; however, how these proposed measures of whole-organism biological …

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently
develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid …