Biological age (BA) is important for clinical monitoring and preventing aging-related
disorders and disabilities. Clinical and/or cellular biomarkers are measured and integrated …

Introduction Aging causes several changes in the immune system, although immune aging
is strongly influenced by individual immunological history, as well as genetic and …

Experimental studies in animal models of aging such as nematodes, fruit flies or mice have
observed that decreased levels of insulin or insulin signaling promotes longevity. In humans …

A metronomic mechanism for the duration control of ontogenetic cycle periods of an animal
is proposed. The components of the proposed metronomic system include the ventricular …

Air pollution (AirPoll) accelerates human aging, as assessed by increased adult mortality
and earlier onset of cardiovascular diseases, and dementia. Socio-economic strata (SES) of …

In this paper, we present demographic, clinical, anamnestic, cognitive, and functional data,
as well as haematological, haematochemical, immunological, and genetic parameters of an …

Tumorigenesis is driven by the gain-of-function mutation or overexpression of oncogenes,
as well as by the inactivation of oncosuppresssive (tumor suppressor) genes due to their …

Objectives To investigate whether a polygenic risk score (PRS) and its interactions with
lifestyle factors are associated with termination of the 'healthspan'(the number of years living …

Background Along with the ageing of society, the absolute prevalence of age-related
diseases is expected to rise, leading to a substantial burden on healthcare systems and …

The increasing aging of the human population is currently and for the coming decades a
major public health issue in many countries, requiring the implementation of global public …