Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women

T Butler, L Glodzik, XH Wang, K Xi, Y Li, H Pan… - Scientific Reports, 2022 - nature.com
In rodents, hypothalamic inflammation plays a critical role in aging and age-related
diseases. Hypothalamic inflammation has not previously been assessed in vivo in humans …

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

M Brand, F Ritzmann, K Kattler, D Milasius, Y Yao… - Respiratory …, 2024 - Springer
Chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis are
incurable. Epithelial senescence, a state of dysfunctional cell cycle arrest, contributes to the …

[HTML][HTML] Anemonefishes: A model system for evolutionary genomics

M Herrera, T Ravasi, V Laudet - F1000Research, 2023 - ncbi.nlm.nih.gov
Anemonefishes are an iconic group of coral reef fish particularly known for their mutualistic
relationship with sea anemones. This mutualism is especially intriguing as it likely prompted …

Can accelerated ageing models inform us on age‐related tauopathies?

ZZ Han, A Fleet, D Larrieu - Aging Cell, 2023 - Wiley Online Library
Ageing is the greatest risk factor of late‐onset neurodegenerative diseases. In the realm of
sporadic tauopathies, modelling the process of biological ageing in experimental animals …

[HTML][HTML] On the perspective of an aging population and its potential impact on drug attrition and pre-clinical cardiovascular safety assessment

B Fermini, DC Bell - Journal of Pharmacological and Toxicological Methods, 2022 - Elsevier
There is no refuting that America's population is growing older: for the first time in US history,
by 2034 older adults (defined as> 65 years of age) are projected to outnumber children …

Integration of fluorescence in situ hybridization and chromosome-length genome assemblies revealed synteny map for guinea pig, naked mole-rat, and human

SA Romanenko, SF Kliver, NA Serdyukova… - Scientific reports, 2023 - nature.com
Descriptions of karyotypes of many animal species are currently available. In addition, there
has been a significant increase in the number of sequenced genomes and an ever …

In vitro and in vivo modeling of normal and leukemic bone marrow niches: cellular senescence contribution to leukemia induction and progression

MJ Salazar-Terreros, JP Vernot - International Journal of Molecular …, 2022 - mdpi.com
Cellular senescence is recognized as a dynamic process in which cells evolve and adapt in
a context dependent manner; consequently, senescent cells can exert both beneficial and …

Metabolome Profiling in Aging Studies

EE Balashova, DL Maslov, OP Trifonova, PG Lokhov… - Biology, 2022 - mdpi.com
Simple Summary Low-molecular-weight substances are participants in all biochemical
processes occurring in the body. Therefore, by measuring them we can obtain new …

The Mediterranean Killifish Aphanius fasciatus (Valenciennes, 1821) (Teleostei: Cyprinodontidae) as a Sentinel Species for Protection of the Quality of Transitional …

MG Lionetto, V Zonno, R Schiavone, ME Giordano… - Water, 2023 - mdpi.com
Transitional waters are fragile ecosystems with high ecological values, representing the
breeding and resting sites for rare and threatened species. They warrant particular attention …

Ageing-associated Phenotypes in Mice

K Xie, D Ehninger - Mechanisms of Ageing and Development, 2023 - Elsevier
Ageing is a continuous process in life featuring progressive damage accumulation that leads
to physiological decline, functional deterioration and ultimately death of an organism. Based …