Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Genome-wide association studies (GWAS) have identified a vast number of variants
associated with various complex human diseases and traits. However, most of these GWAS …

A multitude of sequencing-based and microscopy technologies provide the means to
unravel the relationship between the three-dimensional organization of genomes and key …

The organized three-dimensional chromosome architecture in the cell nucleus provides
scaffolding for precise regulation of gene expression. When the cell changes its identity in …

The 3D conformations of chromosomes are highly variant and stochastic between single
cells. Recent progress in multiplexed 3D FISH imaging, single cell Hi-C and genome …

The genome is partitioned into distinct chromatin compartments with at least two main
classes, a transcriptionally active A and an inactive B compartment, corresponding mostly to …

Among the existing techniques for interrogating the genome structure, Hi-C assays have
become the most performed experiments and constitute the majority of the publicly available …

Understanding 3D genome structure is crucial to learn how chromatin folds and how genes
are regulated through the spatial organization of regulatory elements. Various technologies …

The Integrative Genome Modeling (IGM) platform incorporates information from multiple,
complementary experimental data sources to accurately simulate whole diploid genome …

By studying the folding of chromosomes relative to nuclear bodies in single-cell models, we
reveal specialized subnuclear microenvironments linked to specific gene functions. Our …