APOE2: protective mechanism and therapeutic implications for Alzheimer's disease
Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
Age, APOE and sex: triad of risk of Alzheimer's disease
Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
The genetics of aging: a vertebrate perspective
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …
were discovered in invertebrates. However, the genetics of aging is more complex in …
Genetics of healthy aging and longevity
AR Brooks-Wilson - Human genetics, 2013 - Springer
Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
L Broer, AS Buchman, J Deelen… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …
number of identified disease-susceptibility loci, it is not known which loci influence …
[HTML][HTML] Genetic and epigenetic regulation of human aging and longevity
Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …
and longevity. Whereas environmental and lifestyle factors are important at younger ages …
[HTML][HTML] Heterogeneity in Alzheimer's disease diagnosis and progression rates: implications for therapeutic trials
R Duara, W Barker - Neurotherapeutics, 2023 - Elsevier
The clinical presentation and the pathological processes underlying Alzheimer's disease
(AD) can be very heterogeneous in severity, location, and composition including the amount …
(AD) can be very heterogeneous in severity, location, and composition including the amount …