Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19) …

Abstract The National Genomics Data Center (NGDC), part of the China National Center for
Bioinformation (CNCB), provides a family of database resources to support global academic …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

The global population of older peo-ple is growing at an unprecedented rate, with the number
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …

Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

Abstract How N 6-methyladenosine (m6A), the most abundant mRNA modification,
contributes to primate tissue homeostasis and physiological aging remains elusive. Here …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …