Regeneration plays an instrumental role in biological development and damage repair by
constructing and replacing cells, tissues, and organs. Since regenerative capacity declines …

Organ degeneration refers to the gradual decline in organ function and structure
deterioration that occurs during aging, which represents the greatest risk factor for various …

Accurately measuring biological age is crucial for improving healthcare for the elderly
population. However, the complexity of aging biology poses challenges in how to robustly …

Aging is associated with significant immune functional decline and remodeling, largely
driven by alterations of gene expression and regulation of immune cells. For decades …

The interventions that slow aging or promote healthy aging may provide preventative
measures for age-related diseases (Zhang et al., 2015). Therefore, it is crucial to identify …

The circadian clock regulates cellular and molecular processes in mammals across all
tissues including skeletal muscle, one of the largest organs in the human body …

Background Peripheral nerve damage causes neuroinflammation, which plays a critical role
in establishing and maintaining neuropathic pain (NeP). The mechanisms contributing to …

Aging is the consequence of a lifelong accumulation of stochastic damage to tissues and
cellular components. Advancing age closely associates with elevated markers of innate …

Aging is a complex and heterogeneous process, raising important questions about how
aging is differently impacted by underlying genetics and external factors. Recently …

Hematopoietic stem cells (HSCs) produce all blood cell lineages and maintain life‐long
hematopoiesis. However, the self‐renewal ability and differentiation capacity of HSCs …