The potential for complex computational models of aging

S Farrell, G Stubbings, K Rockwood, A Mitnitski… - Mechanisms of Ageing …, 2021 - Elsevier
The gradual accumulation of damage and dysregulation during the aging of living
organisms can be quantified. Even so, the aging process is complex and has multiple …

[HTML][HTML] Trajectories of body composition during advanced aging in consideration of diet and physical activity: a 20-year longitudinal study

A Jungert, G Eichner, M Neuhäuser-Berthold - Nutrients, 2020 - mdpi.com
This prospective study investigates age-dependent changes in anthropometric data and
body composition over a period of two decades in consideration of physical activity and diet …

[HTML][HTML] How does the environment affect human ageing? An interdisciplinary review

B Plagg, S Zerbe - Journal of Gerontology and …, 2021 - jgerontology-geriatrics.com
The multifactorial process of ageing is one of the biggest biological and medical challenges
of the 21st century with age-related conditions such as cardiovascular diseases …

Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge

AJF Tamman, D Koller, S Nagamatsu… - …, 2024 - nature.com
GrimAge acceleration has previously predicted age-related morbidities and mortality. In the
current study, we sought to examine how GrimAge is associated with genetic predisposition …

Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age

RD Palmer - Aging Medicine, 2022 - Wiley Online Library
As humans age multiple forms of biological decay ensue, and many aspects of human
biology can be measured to determine how far biological machinery has drifted from …

FAM19A5 in vascular aging and osteoporosis: mechanisms and the “calcification paradox”

J Zheng, J He, H Li - Ageing Research Reviews, 2024 - Elsevier
Aging induces a progressive decline in the vasculature's structure and function. Vascular
aging is a determinant factor for vascular ailments in the elderly. FAM19A5, a recently …

Mindfulness-Based Stress Reduction reduces pro-inflammatory gene regulation but not systemic inflammation among older adults: A randomized controlled trial

EK Lindsay, AL Marsland, SW Cole… - Psychosomatic …, 2024 - journals.lww.com
Objective Aging is associated with increased pro-inflammatory gene expression and
systemic inflammation, and psychosocial stress may accelerate these changes. Mindfulness …

Identifying and implementing endpoints for geriatric mice

LA Toth - Comparative Medicine, 2018 - ingentaconnect.com
The types of changes in physical appearance and behavior that occur in elderly people
similarly develop in elderly animals. Signs and symptoms that might cause concern in …

Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice

GR Júnior, NSX Costa, L Belotti… - Ecotoxicology and …, 2019 - Elsevier
Life expectancy is increasing worldwide. Lung aging is a process marked by changes in
multiple morphological, physiological and age-related biomarkers (eg, sirtuins) and is …

The Role of the National Institute on Aging in the Development of the Field of Geroscience

F Sierra, RA Kohanski - Cold Spring …, 2023 - perspectivesinmedicine.cshlp.org
The conceptualization of the field of geroscience, which began about 10 years ago, marks,
together with the publication of “The hallmarks of aging”(see López-Otín C, Blasco MA …