A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Parkinson's disease (PD) is the second most common progressive age-related
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …

Indoxyl sulfate (IS), an agonist of aryl hydrocarbon receptors (AhR), can accumulate in
patients with chronic kidney disease, but its direct effect on bone is not clear. The present …

Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this
premise has driven academic and commercial endeavour to develop dietary supplements …

In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer
cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and …

Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that
leads to changes in life expectancy. In humans, ageing is characterized by greatly increased …

Abstract Sirtuin3 (SIRT3), a mitochondrial deacetylase, has been shown to be involved in
various kidney diseases. In this study, we aimed to clarify the role of SIRT3 in cyclosporine …

Graceful healthy ageing and extended longevity is the most desired goal for human race.
The process of ageing is inevitable and has a profound impact on the gradual deterioration …

In recent years, there has been increasing interest in utilizing Traditional Chinese Medicine
principles and natural bioactive compounds to combat age-related ailments and enhance …