Plant enhancers exhibit both cooperative and additive interactions among their functional elements
Enhancers are cis-regulatory elements that shape gene expression in response to
numerous developmental and environmental cues. In animals, several models have been …
numerous developmental and environmental cues. In animals, several models have been …
The architecture of binding cooperativity between densely bound transcription factors
The binding of transcription factors (TFs) along genomes is restricted to a subset of sites
containing their preferred motifs. TF-binding specificity is often attributed to the co-binding of …
containing their preferred motifs. TF-binding specificity is often attributed to the co-binding of …
[HTML][HTML] Topology regulatory elements: From shaping genome architecture to gene regulation
The importance of 3D genome topology in the control of gene expression is becoming
increasingly apparent, while regulatory mechanisms remain incompletely understood …
increasingly apparent, while regulatory mechanisms remain incompletely understood …
YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing
X chromosome inactivation (XCI) in mammals is mediated by Xist RNA which functions in cis
to silence genes on a single X chromosome in XX female cells, thereby equalising levels of …
to silence genes on a single X chromosome in XX female cells, thereby equalising levels of …
A variegated model of transcription factor function in the immune system
K Chowdhary, C Benoist - Trends in Immunology, 2023 - cell.com
Specific combinations of transcription factors (TFs) control the gene expression programs
that underlie specialized immune responses. Previous models of TF function in …
that underlie specialized immune responses. Previous models of TF function in …
Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription
CC Bell, JJ Balic, L Talarmain, A Gillespie… - Nature Genetics, 2024 - nature.com
Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to
promoters. However, the relationships between TFs, promoters and their associated …
promoters. However, the relationships between TFs, promoters and their associated …
[HTML][HTML] Integrative approaches to study enhancer–promoter communication
P Mach, L Giorgetti - Current Opinion in Genetics & Development, 2023 - Elsevier
The spatiotemporal control of gene expression in complex multicellular organisms relies on
noncoding regulatory sequences such as enhancers, which activate transcription of target …
noncoding regulatory sequences such as enhancers, which activate transcription of target …
[HTML][HTML] Runt-related transcription factors and gene regulatory mechanisms in skeletal development and diseases
H Hojo, S Ohba - Current Osteoporosis Reports, 2023 - Springer
Abstract Purpose of Review Runt-related transcription factors (RUNX) play critical roles in
skeletal development, metabolism, and diseases. In mammals, three RUNX members …
skeletal development, metabolism, and diseases. In mammals, three RUNX members …
[HTML][HTML] Multiomics analysis reveals novel genetic determinants for lens differentiation, structure, and transparency
J Disatham, L Brennan, A Cvekl, M Kantorow - Biomolecules, 2023 - mdpi.com
Recent advances in next-generation sequencing and data analysis have provided new
gateways for identification of novel genome-wide genetic determinants governing tissue …
gateways for identification of novel genome-wide genetic determinants governing tissue …
[HTML][HTML] Pre-hypertrophic chondrogenic enhancer landscape of limb and axial skeleton development
F Darbellay, A Ramisch, L Lopez-Delisle… - Nature …, 2024 - nature.com
Chondrocyte differentiation controls skeleton development and stature. Here we provide a
comprehensive map of chondrocyte-specific enhancers and show that they provide a …
comprehensive map of chondrocyte-specific enhancers and show that they provide a …