While critical for tuning the timing and level of transcription, enhancer communication with
distal promoters is not well understood. Here we bypass the need for sequence-specific …

Deep learning approaches have made significant advances in predicting cell type-specific
chromatin patterns from the identity and arrangement of transcription factor (TF) binding …

Transcriptional enhancers are non-coding DNA elements that regulate gene transcription in
a temporal and tissue-specific manner. Despite advances in computational and …

Transcription factors often regulate numerous target genes. However, ZNF410 controls only
a single gene, CHD4, in human erythroid cells by its highly restricted chromatin occupancy …

The ability to refine transcriptional levels via active repression in an euchromatic context
represents a critical regulatory process during development. While the molecular players of …

Background: Viral nervous necrosis (VNN) is a viral disease threatening the sustainability of
global aquaculture, and affecting over 50 of farmed and ecologically important species. A …

The interplay between nucleosomes and transcription factors leads to programs of gene
expression. Transcriptional silencing involves the generation of a chromatin state that …

Enhancers are cis-regulatory elements that shape gene expression in response to
numerous developmental and environmental cues. In animals, several models have been …

Deciphering the intricate regulatory code governing cell-type-specific gene expression is a
fundamental goal in genetics. Current methods struggle to capture the complex interplay …

The establishment of cell lines with a high protein production is the most crucial objective in
the field of biopharmaceuticals. To this end, efforts have been made to increase transgene …