[HTML][HTML] Chronic inflammation and the hallmarks of aging

JJ Baechle, N Chen, P Makhijani, S Winer… - Molecular …, 2023 - Elsevier
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk

Z Wu, J Qu, W Zhang, GH Liu - Molecular Cell, 2024 - cell.com
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

[HTML][HTML] Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

MT Kabir, MH Rahman, M Shah, MR Jamiruddin… - Biomedicine & …, 2022 - Elsevier
Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …

Epigenetic regulation of cellular senescence

J Crouch, M Shvedova, RJRS Thanapaul… - Cells, 2022 - mdpi.com
Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …

Oncofetal reprogramming in tumour development and progression

A Sharma, C Blériot, J Currenti, F Ginhoux - Nature Reviews Cancer, 2022 - nature.com
Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a
highly vascular microenvironment. These features are similar to those of tumour tissue, in …

The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

Y Sun, X Wang, T Liu, X Zhu, X Pan - Cell & bioscience, 2022 - Springer
Background The global population of older individuals is growing, and ageing is a key risk
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …

Aging and chronic inflammation: highlights from a multidisciplinary workshop

D Saavedra, AL Añé-Kourí, N Barzilai, C Caruso… - Immunity & …, 2023 - Springer
Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …

The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity

D Ali, M Tencerova, F Figeac, M Kassem… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …

Probiotics and gut microbiota: Mechanistic insights into gut immune homeostasis through TLR pathway regulation

H Kaur, SA Ali - Food & Function, 2022 - pubs.rsc.org
Consumption of probiotics as a useful functional food improves the host's wellbeing, and,
when paired with prebiotics (indigestible dietary fibre/carbohydrate), often benefits the host …