Epigenetic clock: A promising biomarker and practical tool in aging
R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
[HTML][HTML] Stress, diet, exercise: common environmental factors and their impact on epigenetic age
F Galkin, O Kovalchuk, D Koldasbayeva… - Ageing Research …, 2023 - Elsevier
Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …
health conditions in clinical and research settings. They have enabled geroscientists to …
[HTML][HTML] Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain
The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …
Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress
Sustained life stress and low socioeconomic status are among the major causes of aging-
related diseases and decreased life expectancy. Experimental rodent models can help to …
related diseases and decreased life expectancy. Experimental rodent models can help to …
The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health
CE Lyons, M Razzoli, A Bartolomucci - Neuroscience & Biobehavioral …, 2023 - Elsevier
Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …
Late‐life exercise mitigates skeletal muscle epigenetic aging
There are functional benefits to exercise in muscle, even when performed late in life, but the
contributions of epigenetic factors to late‐life exercise adaptation are poorly defined. Using …
contributions of epigenetic factors to late‐life exercise adaptation are poorly defined. Using …
Re-wilding model organisms: opportunities to test causal mechanisms in social determinants of health and aging
Social experiences are strongly associated with individuals' health, aging, and survival in
many mammalian taxa, including humans. Despite their role as models of many other …
many mammalian taxa, including humans. Despite their role as models of many other …
[HTML][HTML] Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain
An estimated 250 million people worldwide suffer from knee osteoarthritis (KOA), with older
adults having greater risk. Like other age-related diseases, residents of high-deprivation …
adults having greater risk. Like other age-related diseases, residents of high-deprivation …
[HTML][HTML] A targeted epigenetic clock for the prediction of biological age
Epigenetic clocks were initially developed to track chronological age, but accumulating
evidence indicates that they can also predict biological age. They are usually based on the …
evidence indicates that they can also predict biological age. They are usually based on the …
[HTML][HTML] Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma
K Hu, Z Xu, L Yao, Y Yan, L Zhou, J Li - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Six Gasdermins (GSDM) family members participate in various biological processes
especially pyroptosis, as well as in the initiation and development of many types of cancer …
especially pyroptosis, as well as in the initiation and development of many types of cancer …