Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress

M Razzoli, K Nyuyki-Dufe, BH Chen… - Proceedings of the …, 2023 - National Acad Sciences
Sustained life stress and low socioeconomic status are among the major causes of aging-
related diseases and decreased life expectancy. Experimental rodent models can help to …

Associations between cardiorespiratory fitness and lifestyle‐related factors with DNA methylation‐based ageing clocks in older men: WASEDA'S Health Study

T Kawamura, Z Radak, H Tabata, H Akiyama… - Aging cell, 2024 - Wiley Online Library
DNA methylation‐based age estimators (DNAm ageing clocks) are currently one of the most
promising biomarkers for predicting biological age. However, the relationships between …

[HTML][HTML] Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma

K Hu, Z Xu, L Yao, Y Yan, L Zhou, J Li - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Six Gasdermins (GSDM) family members participate in various biological processes
especially pyroptosis, as well as in the initiation and development of many types of cancer …

Measuring healthy ageing: current and future tools

N Silva, AT Rajado, F Esteves, D Brito, J Apolónio… - Biogerontology, 2023 - Springer
Human ageing is a complex, multifactorial process characterised by physiological damage,
increased risk of age-related diseases and inevitable functional deterioration. As the …

DNA repair‐deficient premature aging models display accelerated epigenetic age

K Perez, A Parras, S Picó, C Rechsteiner… - Aging …, 2024 - Wiley Online Library
Several premature aging mouse models have been developed to study aging and identify
interventions that can delay age‐related diseases. Yet, it is still unclear whether these …

[HTML][HTML] Associations between medium-and long-term exposure to air temperature and epigenetic age acceleration

W Ni, N Nikolaou, CK Ward-Caviness, S Breitner… - Environment …, 2023 - Elsevier
Climate change poses a serious threat to human health worldwide, while aging populations
increase. However, no study has ever investigated the effects of air temperature on …

Age estimation in fishes using epigenetic clocks: Applications to fisheries management and conservation biology

F Piferrer, D Anastasiadi - Frontiers in Marine Science, 2023 - frontiersin.org
The distribution of age classes is a key demographic parameter of populations and thus
proper age estimation is crucial for fisheries management and for conservation biology. Age …

[HTML][HTML] Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites

A Daunay, LM Hardy, Y Bouyacoub… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Aging is a progressive time-dependent biological process affecting differentially individuals,
who can sometimes present exceptional longevity. Epigenetic alterations are one of the …

Development of a novel epigenetic clock resistant to changes in immune cell composition

A Tomusiak, A Floro, R Tiwari, R Riley, H Matsui… - bioRxiv, 2023 - biorxiv.org
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

Re-wilding Model Organisms: Opportunities to test causal mechanisms in social determinants of health and aging

MN Zipple, CC Vogt, MJ Sheehan - Neuroscience & Biobehavioral …, 2023 - Elsevier
Social experiences are strongly associated with individuals' health, aging, and survival in
many mammalian taxa, including humans. Despite their role as models of many other …