New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis

JT Brenna, KSD Kothapalli - Current Opinion in Clinical Nutrition & …, 2022 - journals.lww.com
The mixture of fatty acids available to FADS2 in any tissue defines the product mixture
available for further synthesis of membrane lipids and signaling molecules and may be …

Sex differences in biological systems and the conundrum of menopause: Potential commonalities in post-menopausal disease mechanisms

DA Hart - International Journal of Molecular Sciences, 2022 - mdpi.com
Sex-specific differences in biology and physiology likely start at the time of conception and
progress and mature during the pre-puberty time frame and then during the transitions …

[HTML][HTML] Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer's disease

KL Thrush, DA Bennett, C Gaiteri, S Horvath… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) risk increases exponentially with age and is associated with
multiple molecular hallmarks of aging, one of which is epigenetic alterations. Epigenetic age …

Epigenetic clocks and female fertility timeline: A new approach to an old issue?

L Li Piani, P Vigano', E Somigliana - Frontiers in cell and …, 2023 - frontiersin.org
Worldwide increase in life expectancy has boosted research on aging. Overcoming the
concept of chronological age, higher attention has been addressed to biological age, which …

Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing

O Neytchev, H Erlandsson, A Witasp… - Journal of Internal …, 2024 - Wiley Online Library
Background Chronic kidney disease (CKD) is an age‐related disease that displays multiple
features of accelerated ageing. It is currently unclear whether the two treatment options for …

Early origins of health and disease risk: The case for investigating adverse exposures and biological aging in utero, across childhood, and into adolescence

L Etzel, P Garrett‐Petters… - Child Development …, 2023 - Wiley Online Library
In this article, we suggest that aging and development are two sides of the same coin, and
that developing a comprehensive understanding of health and disease risk requires …

Development of epigenetic biomarkers in aquatic organisms

D Anastasiadi, A Beemelmanns - Epigenetics in aquaculture, 2023 - Wiley Online Library
Biomarkers, as measurable characteristics of normal or pathogenic processes, are used in
the context of human health and to monitor animal welfare and ecosystem status. Epigenetic …

Predator–prey systems as models for integrative research in biology: the value of a non-consumptive effects framework

A Batabyal - Journal of Experimental Biology, 2023 - journals.biologists.com
Predator–prey interactions are a cornerstone of many ecological and evolutionary
processes that influence various levels of biological organization, from individuals to …

Age determination through DNA methylation patterns in fingernails and toenails

K Fokias, L Dierckx, W Van de Voorde… - Forensic Science …, 2023 - Elsevier
Over the past decade, age prediction based on DNA methylation has become a vastly
investigated topic; many age prediction models have been developed based on different …

Aging clock based on nucleosome reorganisation derived from cell‐free DNA

M Shtumpf, S Jeong, M Bikova, H Mamayusupova… - Aging …, 2024 - Wiley Online Library
Aging induces systematic changes in the distribution of nucleosomes, which affect gene
expression programs. Here we reconstructed nucleosome maps based on cell‐free DNA …