Age Prediction Using DNA Methylation Heterogeneity Metrics

DI Karetnikov, SE Romanov, VP Baklaushev… - International Journal of …, 2024 - mdpi.com
Dynamic changes in genomic DNA methylation patterns govern the epigenetic
developmental programs and accompany the organism's aging. Epigenetic clock (eAge) …

Healthy Japanese dietary pattern is associated with slower biological aging in older men: WASEDA'S health study

T Kawamura, M Higuchi, T Ito, R Kawakami… - Frontiers in …, 2024 - frontiersin.org
Aging is the greatest risk factor for numerous diseases and mortality, and establishing
geroprotective interventions targeting aging is required. Previous studies have suggested …

Building Minimized Epigenetic Clock by iPlex MassARRAY Platform

E Davydova, A Perenkov, M Vedunova - Genes, 2024 - mdpi.com
Epigenetic clocks are valuable tools for estimating both chronological and biological age by
assessing DNA methylation levels at specific CpG dinucleotides. While conventional …

A cautionary note on altered pace of aging in the COVID-19 era

MAH Attia - Forensic Science International: Genetics, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is highly age-dependent due to hi-jacking
the molecular control of the immune cells by the severe acute respiratory syndrome-corona …

Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies

A Niehues, D Bizzarri, MJT Reinders, PE Slagboom… - BMC genomics, 2022 - Springer
Population-scale expression profiling studies can provide valuable insights into biological
and disease-underlying mechanisms. The availability of phenotypic traits is essential for …

Maternal adversity and epigenetic age acceleration predict heightened emotional reactivity in offspring: Implications for intergenerational transmission of risk

BG McKenna, J Choi, PA Brennan, A K. Knight… - Research on Child and …, 2023 - Springer
Black American women are disproportionately exposed to adversities that may have an
intergenerational impact on mental health. The present study examined whether maternal …

The state of the art in cost-benefit of HTS methods for stock assessment: An overview

G Rodríguez-Rodríguez, HM Ballesteros… - Frontiers in Marine …, 2022 - frontiersin.org
Over the past two decades, enormous progresses have been made in high-throughput
sequencing (HTS) method development. This fact unveiled the potential usefulness of HTS …

ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age

K Perez, A Parras, C Rechsteiner, A Haghani… - bioRxiv, 2022 - biorxiv.org
Over the last decades, several premature aging mouse models have been developed to
study aging and identify interventions that can delay age-related diseases. Yet, it is still …

Age-related patterns in mandibular third molar eruption: presenting new forensic age assessment reference data from a Chinese population

M Timme, J Viktorov, L Steffens, A Streeter… - … Science, Medicine and …, 2024 - Springer
Valid reference data are essential for reliable forensic age assessment procedures in the
living, a fact that extends to the trait of mandibular third molar eruption in dental panoramic …

Variational autoencoders to predict DNA-methylation age and provide biological insights in age-related health and disease

S Steyaert, A Verhelle, W Van Criekinge - medRxiv, 2023 - medrxiv.org
Motivation: Epigenetic ageing clocks based on age-associated changes in DNA-methylation
(DNAm) profiles have shown great potential as predictors to quantify age-related health and …