[HTML][HTML] Telomere dysfunction in ageing and age-related diseases
Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …
dysfunction. Telomere shortening and damage are recognized causes of cellular …
[HTML][HTML] COVID-19 mechanisms in the human body—What we know so far
More than one and a half years have elapsed since the commencement of the coronavirus
disease 2019 (COVID-19) pandemic, and the world is struggling to contain it. Being caused …
disease 2019 (COVID-19) pandemic, and the world is struggling to contain it. Being caused …
[HTML][HTML] Open science saves lives: lessons from the COVID-19 pandemic
In the last decade Open Science principles have been successfully advocated for and are
being slowly adopted in different research communities. In response to the COVID-19 …
being slowly adopted in different research communities. In response to the COVID-19 …
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells
D Zhou, M Borsa, AK Simon - Aging Cell, 2021 - Wiley Online Library
The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …
related diseases in an increasing number of people represent an enormous burden for …
[HTML][HTML] The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging
ES Epel - Ageing Research Reviews, 2020 - Elsevier
Geroscience offers a counterpoint to the challenged pursuit of curing diseases of aging, by
focusing on slowing the biological aging process for extended healthspan earlier in life …
focusing on slowing the biological aging process for extended healthspan earlier in life …
[HTML][HTML] Telomeres and mitochondrial metabolism: implications for cellular senescence and age-related diseases
X Gao, X Yu, C Zhang, Y Wang, Y Sun, H Sun… - Stem cell reviews and …, 2022 - Springer
Cellular senescence is an irreversible cell arrest process, which is determined by a variety of
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …
Age-related vulnerability to coronavirus disease 2019 (COVID-19): biological, contextual, and policy-related factors
EM Crimmins - Public Policy & Aging Report, 2020 - academic.oup.com
The detailed facts surrounding the coronavirus disease 2019 (COVID-19) pandemic are still
evolving; however, one of the most shocking aspects of the COVID-19 pandemic is how …
evolving; however, one of the most shocking aspects of the COVID-19 pandemic is how …
[HTML][HTML] Short telomeres increase the risk of severe COVID-19
A Froidure, M Mahieu, D Hoton, PF Laterre… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Telomeres are non-coding DNA sequences that protect chromosome ends and shorten with
age. Short telomere length (TL) is associated with chronic diseases and …
age. Short telomere length (TL) is associated with chronic diseases and …
[HTML][HTML] Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: a cohort study in UK Biobank
Background Older age is the most powerful risk factor for adverse coronavirus disease-19
(COVID-19) outcomes. It is uncertain whether leucocyte telomere length (LTL), previously …
(COVID-19) outcomes. It is uncertain whether leucocyte telomere length (LTL), previously …
[HTML][HTML] Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-
19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to …
19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to …