Activation of immunosuppressive network in the aging process

A Salminen - Ageing research reviews, 2020 - Elsevier
Chronic low-grade inflammation has a key role in the aging process, a state called
inflammaging. It is known that the chronic inflammatory condition generates counteracting …

The immune system and the impact of zinc during aging

H Haase, L Rink - Immunity & Ageing, 2009 - Springer
The trace element zinc is essential for the immune system, and zinc deficiency affects
multiple aspects of innate and adaptive immunity. There are remarkable parallels in the …

Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions

A Salminen - Journal of Molecular Medicine, 2021 - Springer
The functional competence of the immune system gradually declines with aging, a process
called immunosenescence. The age-related remodelling of the immune system affects both …

An evolutionary perspective on the mechanisms of immunosenescence

DP Shanley, D Aw, NR Manley, DB Palmer - Trends in immunology, 2009 - cell.com
There is an accumulating body of evidence that a decline in immune function with age is
common to most if not all vertebrates. For instance, age-associated thymic involution seems …

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

A Salminen, K Kaarniranta, A Kauppinen - Cellular and Molecular Life …, 2019 - Springer
The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …

Zinc: dietary intake and impact of supplementation on immune function in elderly

E Mocchegiani, J Romeo, M Malavolta, L Costarelli… - Age, 2013 - Springer
The diet in the elderly does not provide a sufficient level of nutrients needed to maintain an
adequate healthy status leading to micronutrient deficiencies and impaired immune …

NK phenotypic markers and IL2 response in NK cells from elderly people

F Borrego, MC Alonso, MD Galiani, J Carracedo… - Experimental …, 1999 - Elsevier
Immunosenescence is a process that primarily affects the T cell compartment of the immune
system, although age-associated immunological alterations have also been demonstrated in …

Moderate exercise may attenuate some aspects of immunosenescence

N Drela, E Kozdron, P Szczypiorski - BMC geriatrics, 2004 - Springer
Background Immunosenescence is related to the deterioration of many immune functions,
which may be manifested in increased susceptibility to infection, cancer, and autoimmunity …

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

A Salminen, K Kaarniranta, A Kauppinen - Ageing research reviews, 2018 - Elsevier
A chronic low-grade inflammation is one of the hallmarks of the aging process. This
gradually augmenting inflammatory state has been termed inflammaging. Inflammaging is …

Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice

L Zhao, L Sun, H Wang, H Ma, G Liu… - Journal of Leucocyte …, 2007 - academic.oup.com
A progressive decline in the integrity of the immune system is one of the physiologic
changes during aging. The frequency of autoimmune diseases or immune disorders …