Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Several factors (the lengthening of the average and, to a lesser extent, of the maximum
human life span; the increase in percentage of elderly in the population and in the …

Mesenchymal stem cells (MSC) comprise a promising tool for cellular therapy. These cells
are usually culture expanded prior to their application. However, a precise molecular …

Caloric restriction has been shown to increase longevity in organisms ranging from yeast to
mammals. In some organisms, this has been associated with a decreased fat mass and …

Background. The compression of morbidity hypothesis predicts that, in order to achieve their
extreme old age, centenarians markedly delay or even escape diseases that would …

Aging is commonly defined as the accumulation of diverse deleterious changes occurring in
cells and tissues with advancing age that are responsible for the increased risk of disease …

Background Diagnostics of the human ageing process may help predict future healthcare
needs or guide preventative measures for tackling diseases of older age. We take a …

ContextIndividuals with exceptional longevity have a lower incidence and/or significant
delay in the onset of age-related disease, and their family members may inherit biological …

Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …

Global demethylation is required for early zygote development to establish stem cell
pluripotency, yet our findings reiterate this epigenetic reprogramming event in somatic cells …