Early life adversity across different cell-types in the brain

G Warhaftig, D Almeida, G Turecki - Neuroscience & Biobehavioral …, 2023 - Elsevier
Early life adversity (ELA)-which includes physical, psychological, emotional, and sexual
abuse is one of the most common predictors to diverse psychopathologies later in …

Stressed Microglia: Neuroendocrine–Neuroimmune Interactions in the Stress Response

MK Sequeira, JL Bolton - Endocrinology, 2023 - academic.oup.com
Stressful life experiences are associated with the development of neuropsychiatric disorders
like depression. Emerging evidence indicates that microglia, the specialized resident …

[HTML][HTML] Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress

M Rincón-Cortés - Addiction neuroscience, 2023 - Elsevier
In humans, exposure to early life stress (ELS) is an established risk factor for the
development of substance use disorders (SUDs) during later life. Similarly, rodents exposed …

The outcomes of maternal immune activation induced with the viral mimetic poly I: C on microglia in exposed rodent offspring

SM Loewen, AM Chavesa, CJ Murray, ME Traetta… - 2023 - karger.com
Maternal immune activation (MIA) can result from a variety of maternal inflammatory factors,
including metabolic disorders, nutritional deficits, infections, and psychosocial stress. MIA …

[HTML][HTML] Long-term impact of early life stress on serotonin connectivity

R Ramkumar, M Edge-Partington, DJ Terstege… - Biological …, 2024 - Elsevier
Background Chronic childhood stress is a prominent risk factor for developing affective
disorders, yet mechanisms underlying this association remain unclear. Maintenance of …

[HTML][HTML] Transient impairment in microglial function causes sex-specific deficits in synaptic and hippocampal function in mice exposed to early adversity

S Ahmed, B Polis, S Jamwal, BG Sanganahalli… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abnormal development and function of the hippocampus are two of the most consistent
findings in humans and rodents exposed to early life adversity, with males often being more …

[HTML][HTML] Neighborhood-level social vulnerability and individual-level cognitive and motor functioning over time in older non-Latino Black and Latino adults

M Lamar, KN Kershaw, SE Leurgans… - Frontiers in Human …, 2023 - frontiersin.org
Introduction Despite known health disparities in cognitive aging, a comprehensive rationale
for the increased burden in older minoritized populations including non-Latino Black and …

Maternal immune activation with toll‐like receptor 7 agonist during mid‐gestation alters juvenile and adult developmental milestones and behavior

JA Sheng, SA Tobet - Journal of Neuroendocrinology, 2024 - Wiley Online Library
Infections during pregnancy are associated with increased risk for adult neuropsychiatric
disease, such as major depressive disorder, schizophrenia, and autism spectrum disorder …

[PDF][PDF] Addiction Neuroscience

M Rincón-Cortés - Addiction, 2023 - researchgate.net
abstract In humans, exposure to early life stress (ELS) is an established risk factor for the
development of substance use disorders (SUDs) during later life. Similarly, rodents exposed …

Stress during pregnancy leads to long-term consequences in the offspring

JA Sheng, S Tobet, B Smith, B Myers, T Hale… - 2024 - mountainscholar.org
Neuropsychiatric disorders encompass a wide range of conditions that affect neurological
health and brain function and lead to disabilities worldwide. Such disorders include, but are …