[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Effects of age, sex, serostatus, and underlying comorbidities on humoral response post-SARS-CoV-2 Pfizer-BioNTech mRNA vaccination: a systematic review

KI Notarte, AT Ver, JV Velasco, A Pastrana… - Critical reviews in …, 2022 - Taylor & Francis
With the advent of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
pandemic, several vaccines have been developed to mitigate its spread and prevent …

Increased risk for COVID‐19 breakthrough infection in fully vaccinated patients with substance use disorders in the United States between December 2020 and …

L Wang, QQ Wang, PB Davis, ND Volkow… - World …, 2022 - Wiley Online Library
Individuals with substance use disorders (SUDs) are at increased risk for COVID‐19
infection and for adverse outcomes of the infection. Though vaccines are highly effective …

Immune system and COVID-19 by sex differences and age

T Ciarambino, O Para, M Giordano - Women's Health, 2021 - journals.sagepub.com
In COVID-19 disease, are reported gender differences in relation to severity and death. The
aim of this review is to highlight gender differences in the immune response to COVID-19 …

[HTML][HTML] Markers of T cell senescence in humans

W Xu, A Larbi - International journal of molecular sciences, 2017 - mdpi.com
Many countries are facing the aging of their population, and many more will face a similar
obstacle in the near future, which could be a burden to many healthcare systems. Increased …

[HTML][HTML] Towards effective COVID‑19 vaccines: Updates, perspectives and challenges

D Calina, AO Docea, D Petrakis… - International …, 2020 - spandidos-publications.com
In the current context of the pandemic triggered by SARS-COV-2, the immunization of the
population through vaccination is recognized as a public health priority. In the case of SARS …

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

M Almanan, J Raynor, I Ogunsulire, A Malyshkina… - Science …, 2020 - science.org
Aging results in profound immune dysfunction, resulting in the decline of vaccine
responsiveness previously attributed to irreversible defects in the immune system. In …

From DNA damage to mutations: All roads lead to aging

J Vijg - Ageing Research Reviews, 2021 - Elsevier
Damage to the repository of genetic information in cells has plagued life since its very
beginning 3–4 billion years ago. Initially, in the absence of an ozone layer, especially …

[HTML][HTML] The untwining of immunosenescence and aging

W Xu, G Wong, YY Hwang, A Larbi - Seminars in immunopathology, 2020 - Springer
From a holistic point of view, aging results from the cumulative erosion of the various
systems. Among these, the immune system is interconnected to the rest as immune cells are …

Oral and intranasal vaccines against SARS‐CoV‐2: Current progress, prospects, advantages, and challenges

S Kar, P Devnath, TB Emran, TE Tallei… - Immunity …, 2022 - Wiley Online Library
Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
caused a deadly pandemic in the 21st century, resulting in many deaths, economic loss, and …