Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
In contrast to other respiratory viruses, children have less severe symptoms when infected
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …

Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics

JB Steinman, FM Lum, PPK Ho… - Proceedings of the …, 2020 - National Acad Sciences
The reduced development of COVID-19 for children compared to adults provides some
tantalizing clues on the pathogenesis and transmissibility of this pandemic virus. First, ACE2 …

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

R Pique-Regi, R Romero, AL Tarca, F Luca, Y Xu… - Elife, 2020 - elifesciences.org
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million …

Novel coronavirus 2019 transmission risk in educational settings

CF Yung, K Kam, KD Nadua, CY Chong… - Clinical Infectious …, 2021 - academic.oup.com
Transmission risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
schools is unknown. Our investigations, especially in preschools, could not detect SARS …

Single-cell transcriptomic atlas of primate cardiopulmonary aging

S Ma, S Sun, J Li, Y Fan, J Qu, L Sun, S Wang, Y Zhang… - Cell research, 2021 - nature.com
Aging is a major risk factor for many diseases, especially in highly prevalent
cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease …

Guided construction of single cell reference for human and mouse lung

M Guo, MP Morley, C Jiang, Y Wu, G Li, Y Du… - Nature …, 2023 - nature.com
Accurate cell type identification is a key and rate-limiting step in single-cell data analysis.
Single-cell references with comprehensive cell types, reproducible and functionally …

Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium

BA Schuler, AC Habermann, EJ Plosa… - The Journal of …, 2021 - Am Soc Clin Investig
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) novel coronavirus
2019 (COVID-19) global pandemic has led to millions of cases and hundreds of thousands …

High altitude reduces infection rate of COVID-19 but not case-fatality rate

J Segovia-Juarez, JM Castagnetto… - Respiratory physiology & …, 2020 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a pandemic caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is suggested that life at high altitude …

Understanding the age divide in COVID-19: why are children overwhelmingly spared?

K Lingappan, H Karmouty-Quintana… - … of Physiology-Lung …, 2020 - journals.physiology.org
The rapid emergence and subsequent global dissemination of SARS-CoV-2 disease
(COVID-19) has resulted in over 4 million cases worldwide. The disease has a marked …

COVID-19 in children with asthma

G Chatziparasidis, A Kantar - Lung, 2021 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects both children and
adults but epidemiological and clinical data demonstrate that children are less likely to have …