Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …

The conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded
the field of frailty, including social and behavioral domains with critical interaction between …

Biological age captures a person's age-related risk of unfavorable outcomes using
biophysiological information. Multivariate biological age measures include frailty scores and …

Background Cancer and its treatments may accelerate aging in survivors; however, research
has not examined epigenetic markers of aging in longer term breast cancer survivors. This …

DNA methylation age acceleration (DNAmAA, derived from an epigenetic clock) and relative
leukocyte telomere length (rLTL) are widely accepted biomarkers of aging. Nevertheless, it …

Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …

Background There is a large body of evidence linking muscular weakness, as determined by
low grip strength, to a host of negative ageing‐related health outcomes. Given these links …

A key hallmark in the age‐related dysfunction of physiological systems is disruption related
to the regulation of inflammation, often resulting in a chronic, low‐grade inflammatory state …

Stressful life events have been linked to declining health, and inflammation has been
proposed as a physiological mechanism that might explain this association. Using 828 …