Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology
The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …
between genetic and environmental factors. On the one hand, hundreds of genes …
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
A systematic evaluation of single-cell RNA-sequencing imputation methods
Background The rapid development of single-cell RNA-sequencing (scRNA-seq)
technologies has led to the emergence of many methods for removing systematic technical …
technologies has led to the emergence of many methods for removing systematic technical …
Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn's disease
Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …
[HTML][HTML] Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics
Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell
compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and …
compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and …
Heterogeneity of HSC s in a Mouse Model of NASH
Background and Aims In clinical and experimental NASH, the origin of the scar‐forming
myofibroblast is the HSC. We used foz/foz mice on a Western diet to characterize in detail …
myofibroblast is the HSC. We used foz/foz mice on a Western diet to characterize in detail …
Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response
The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …
Connecting past and present: single-cell lineage tracing
C Chen, Y Liao, G Peng - Protein & Cell, 2022 - academic.oup.com
Central to the core principle of cell theory, depicting cells' history, state and fate is a
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …
Identification of novel regulators required for early development of vein pattern in the cotyledons by single‐cell RNA‐sequencing
Z Liu, J Wang, Y Zhou, Y Zhang, A Qin, X Yu… - The Plant …, 2022 - Wiley Online Library
The leaf veins of higher plants contain a highly specialized vascular system comprised of
xylem and phloem cells that transport water, organic compounds and mineral nutrients. The …
xylem and phloem cells that transport water, organic compounds and mineral nutrients. The …