Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

An ELOVL2-based epigenetic clock for forensic age prediction: a systematic review

E Paparazzo, V Lagani, S Geracitano… - International Journal of …, 2023 - mdpi.com
The prediction of chronological age from methylation-based biomarkers represents one of
the most promising applications in the field of forensic sciences. Age-prediction models …

Evidence for biological age acceleration and telomere shortening in COVID-19 survivors

A Mongelli, V Barbi, M Gottardi Zamperla… - International journal of …, 2021 - mdpi.com
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst
cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine …

[HTML][HTML] Chronological age prediction: developmental evaluation of DNA methylation-based machine learning models

H Fan, Q Xie, Z Zhang, J Wang, X Chen… - … in Bioengineering and …, 2022 - frontiersin.org
Epigenetic clock, a highly accurate age estimator based on DNA methylation (DNAm) level,
is the basis for predicting mortality/morbidity and elucidating the molecular mechanism of …

Artificial neural network, predictor variables and sensitivity threshold for DNA methylation-based age prediction using blood samples

Z Thong, JYY Tan, ES Loo, YW Phua, XLS Chan… - Scientific reports, 2021 - nature.com
Regression models are often used to predict age of an individual based on methylation
patterns. Artificial neural network (ANN) however was recently shown to be more accurate …

[HTML][HTML] Development and inter-laboratory validation of the VISAGE enhanced tool for age estimation from semen using quantitative DNA methylation analysis

A Heidegger, A Pisarek, M de la Puente… - Forensic Science …, 2022 - Elsevier
The analysis of DNA methylation has become an established method for chronological age
estimation. This has triggered interest in the forensic community to develop new methods for …

The biological age of the heart is consistently younger than chronological age

S Pavanello, M Campisi, A Fabozzo, G Cibin… - Scientific Reports, 2020 - nature.com
Chronological age represents the main factor in donor selection criteria for organ
transplantation, however aging is very heterogeneous. Defining the biological aging of …

[HTML][HTML] Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites

A Daunay, LM Hardy, Y Bouyacoub… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Aging is a progressive time-dependent biological process affecting differentially individuals,
who can sometimes present exceptional longevity. Epigenetic alterations are one of the …

Pyrosequencing: Current forensic methodology and future applications—A review

M Ghemrawi, NF Tejero, G Duncan… - Electrophoresis, 2023 - Wiley Online Library
The recent development of small, single‐amplicon‐based benchtop systems for
pyrosequencing has opened up a host of novel procedures for applications in forensic …

A new robust epigenetic model for forensic age prediction

A Montesanto, P D'Aquila, V Lagani… - Journal of forensic …, 2020 - Wiley Online Library
Forensic DNA phenotyping refers to an emerging field of forensic sciences aimed at the
prediction of externally visible characteristics of unknown sample donors directly from …