Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

Sexual dimorphisms exist in multiple domains, from learning and memory to neurocognitive
disease, and even in the immune system. Male sex has been associated with increased …

Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting
subclinical, proinflammatory status, currently recognized as the main risk factor for …

Sex and gender differences play a significant role in the pathogenesis, clinical presentation,
and treatment outcomes of various diseases. These differences arise from a complex …

By definition, aging is a natural, gradual and continuous process. On the other hand, frailty
reflects the increase in vulnerability to stressors and shortens the time without disease …

Abstract Background The Neutrophil-to-lymphocyte ratio (NLR) is a marker of poor
prognosis in hospitalized older patients with different diseases, but there is still no …

The recently identified syndrome known as Long COVID (LC) is characterized by a
constellation of debilitating conditions that impair both physical and cognitive functions, thus …

Human health is strongly mediated by the gut microbiota ecosystem, which, in turn, depends
not only on its state but also on its dynamics and how it responds to perturbations. Healthy …

Most of the elderly population is afflicted by periodontal diseases, creating a health burden
worldwide. Cellular senescence is one of the hallmarks of aging and associated with several …

Immune system aging is becoming a field of increasing public health interest because of
prolonged life expectancy, which is not paralleled by an increase in health expectancy. As …