Telomere dysfunction in ageing and age-related diseases
Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …
dysfunction. Telomere shortening and damage are recognized causes of cellular …
Skin aging, cellular senescence and natural polyphenols
E Csekes, L Račková - International journal of molecular sciences, 2021 - mdpi.com
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …
impacting its morphology and function. Senescent cells have been found to accumulate with …
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
Understanding long COVID; mitochondrial health and adaptation—old pathways, new problems
Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”,
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …
[HTML][HTML] Factors modulating COVID-19: A mechanistic understanding based on the adverse outcome pathway framework
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows
that outcomes are markedly heterogeneous between patients. This requires identifying the …
that outcomes are markedly heterogeneous between patients. This requires identifying the …
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
J Aguado, AA Amarilla, A Taherian Fard, EA Albornoz… - Nature aging, 2023 - nature.com
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
ABO blood system and COVID-19 susceptibility: anti-A and anti-B antibodies are the key points
Á Tamayo-Velasco, MJ Peñarrubia-Ponce… - Frontiers in …, 2022 - frontiersin.org
The implication of the ABO blood group in COVID-19 disease was formulated early, at the
beginning of the COVID-19 pandemic more than 2 years ago. It has now been established …
beginning of the COVID-19 pandemic more than 2 years ago. It has now been established …
The nervous system during COVID‐19: Caught in the crossfire
NR Natale, JR Lukens, WA Petri Jr - Immunological reviews, 2022 - Wiley Online Library
SUMMARY SARS‐CoV‐2, the virus that causes coronavirus disease (COVID)‐19, has
become a persistent global health threat. Individuals who are symptomatic for COVID‐19 …
become a persistent global health threat. Individuals who are symptomatic for COVID‐19 …
SARS-CoV-2 and the DNA damage response
RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …
The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs
AS Mekawy, Z Alaswad, AA Ibrahim… - Journal of Genetic …, 2022 - Springer
DNA damage and genome instability in host cells are introduced by many viruses during
their life cycles. Severe acute respiratory syndrome coronaviruses (SARS-CoVs) …
their life cycles. Severe acute respiratory syndrome coronaviruses (SARS-CoVs) …