[HTML][HTML] Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes

K Richter, V Grau - Pharmacological Research, 2023 - Elsevier
Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the
neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate …

Nicotinic acetylcholine receptors in the respiratory tract

MI Hollenhorst, G Krasteva-Christ - Molecules, 2021 - mdpi.com
Nicotinic acetylcholine receptors (nAChR) are widely distributed in neuronal and non-
neuronal tissues, where they play diverse physiological roles. In this review, we highlight the …

Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations

ET Roxlau, O Pak, S Hadzic… - European …, 2023 - Eur Respiratory Soc
Background Electronic cigarette (e-cigarette) vapour is gaining popularity as an alternative
to tobacco smoking and can induce acute lung injury. However, the specific role of nicotine …

An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions

J Routhier, S Pons, ML Freidja, V Dalstein… - Nature …, 2021 - nature.com
Abstract Chronic Obstructive Pulmonary Disease is a generally smoking-linked major cause
of morbidity and mortality. Genome-wide Association Studies identified a locus including a …

Nicotinic receptors as SARS-CoV-2 spike co-receptors?

V Dormoy, JM Perotin, P Gosset, U Maskos… - Medical …, 2022 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) play an important role in homeostasis and
respiratory diseases. Controversies regarding the association between COVID-19 …

Pathophysiology, therapeutic targets, and future therapeutic alternatives in COPD: Focus on the importance of the cholinergic system

F Gomes, SL Cheng - Biomolecules, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by
airway limitation and changes in airway structure. It has a high global burden of mortality …

[HTML][HTML] Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina

F Esteso, NS Tissera, JM O'Connor… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Given the increasing complexity of cancer care, multidisciplinary tumor boards have become
essential in daily clinical oncology practice. The Project Extension for Community …

Neuroanatomy of lymphoid organs: Lessons learned from whole‐tissue imaging studies

Y Cao, H Chen, J Yang - European Journal of Immunology, 2023 - Wiley Online Library
Decades of extensive research have documented the presence of neural innervations of
sensory, sympathetic, or parasympathetic origin in primary and secondary lymphoid organs …

Design, Synthesis, and Structure–Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that …

AJ Hone, U Santiago, PJ Harvey, B Tekarli… - Journal of Medicinal …, 2024 - ACS Publications
The spike-protein of SARS-CoV-2 has a distinctive amino-acid sequence (682RRARS686)
that forms a cleavage site for the enzyme furin. Strikingly, the structure of the spike-protein …

Targeting ion channels for the treatment of lung cancer

L Zhang, S Bing, M Dong, X Lu, Y Xiong - Biochimica et Biophysica Acta …, 2021 - Elsevier
Lung cancer is caused by several environmental and genetic variables and is globally
associated with elevated morbidity and mortality. Among these variables, membrane-bound …