Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Aging causes a functional decline in tissues throughout the body that may be delayed by
caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as …

Background Environmental and lifestyle changes, in addition to the ageing of populations,
are generally believed to account for the rapid global increase in type 2 diabetes prevalence …

The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Sarcopenic obesity, a chronic condition, is today a major public health problem with
increasing prevalence worldwide, which is due to progressively aging populations, the …

SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …