The structural and functional complexity of the integrative hypothalamus

H Fong, J Zheng, D Kurrasch - Science, 2023 - science.org
The hypothalamus (“hypo” meaning below, and “thalamus” meaning bed) consists of
regulatory circuits that support basic life functions that ensure survival. Sitting at the interface …

Maternal immune activation affects socio-communicative behavior in adult rats

K Gzieło, D Piotrowska, E Litwa, P Popik, A Nikiforuk - Scientific reports, 2023 - nature.com
A wide body of evidence suggests a relationship between maternal immune activation (MIA)
and neurodevelopmental disorders such as autism spectrum disorder (ASD). Since social …

[HTML][HTML] Maternal immune activation alters placental histone-3 lysine-9 tri-methylation, offspring sensorimotor processing, and hypothalamic transposable element …

H DeRosa, A Smith, L Geist, A Cheng, RG Hunter… - Neurobiology of …, 2023 - Elsevier
Animal models of maternal immune activation (MIA) are central to identifying the biological
mechanisms that underly the association between prenatal infection and neuropsychiatric …

Prenatal and postnatal challenges affect the hypothalamic molecular pathways that regulate hormonal levels

SL Rodriguez-Zas, NL Southey, L Rund, AM Antonson… - Plos one, 2023 - journals.plos.org
This study aimed to improve our understanding of how the hypothalamus mediates the
effects of prenatal and postnatal challenges on behavior and sensitivity to stimuli. A pig …

[HTML][HTML] Sensory input, sex, and function shape hypothalamic cell type development

HS Kaplan, BL Logeman, K Zhang, C Santiago… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Mammalian behavior and physiology undergo dramatic changes in early life. Young animals
rely on conspecifics to meet their homeostatic needs, until weaning and puberty initiate …

Immune and metabolic challenges induce changes in pain sensation and related pathways in the hypothalamus

SL Rodriguez-Zas, RA Nowak… - Physiological …, 2024 - journals.physiology.org
The hypothalamic molecular processes participate in the regulation of the neuro-immune-
endocrine system, including hormone, metabolite, chemokine circulation, and …

Maternal immune activation with toll‐like receptor 7 agonist during mid‐gestation alters juvenile and adult developmental milestones and behavior

JA Sheng, SA Tobet - Journal of Neuroendocrinology, 2024 - Wiley Online Library
Infections during pregnancy are associated with increased risk for adult neuropsychiatric
disease, such as major depressive disorder, schizophrenia, and autism spectrum disorder …

[PDF][PDF] AND EXPOSURE TO CIRCADIAN DISRUPTION DURING ADOLESCENCE: EXPLORING THE TWO-HIT MODEL OF NEURODEVELOPMENTAL DISORDERS

TC Delorme, N Huebener, DM Arcego… - … activation in relation …, 2023 - escholarship.mcgill.ca
Chapter 2 presented behavioral and microglial findings after adulthood subjected to LL in
mice exposed to prenatal poly IC. Chapter 3 builds upon these findings, by investigating the …

Stress during pregnancy leads to long-term consequences in the offspring

JA Sheng, S Tobet, B Smith, B Myers, T Hale… - 2024 - mountainscholar.org
Neuropsychiatric disorders encompass a wide range of conditions that affect neurological
health and brain function and lead to disabilities worldwide. Such disorders include, but are …