The Antimicrobial Potential of the Neem Tree Azadirachta indica

MR Wylie, DS Merrell - Frontiers in pharmacology, 2022 - frontiersin.org
Azadirachta indica (A. Juss), also known as the neem tree, has been used for millennia as a
traditional remedy for a multitude of human ailments. Also recognized around the world as a …

Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID‐19 severity: A systematic review with meta‐analysis

W Saengsiwaritt, J Jittikoon… - Reviews in medical …, 2022 - Wiley Online Library
Abstract Novel coronavirus disease 2019 (COVID‐19) poses a global threat, due to its
fluctuating frequency and lethality. Published data revealed associations of COVID‐19 …

Causal effects of COVID‐19 on cancer risk: A Mendelian randomization study

J Li, H Bai, H Qiao, C Du, P Yao… - Journal of Medical …, 2023 - Wiley Online Library
In contemporary literature, little attention has been paid to the association between
coronavirus disease‐2019 (COVID‐19) and cancer risk. We performed the Mendelian …

Coronavirus infection and cholesterol metabolism

J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

Identification of natural inhibitors against SARS-CoV-2 drugable targets using molecular docking, molecular dynamics simulation, and MM-PBSA approach

PP Kushwaha, AK Singh, T Bansal, A Yadav… - Frontiers in cellular …, 2021 - frontiersin.org
The present study explores the SARS-CoV-2 drugable target inhibition efficacy of
phytochemicals from Indian medicinal plants using molecular docking, molecular dynamics …

Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy

X Peng, W Pan, F Jiang, W Chen, Z Qi, W Peng… - Pharmacological …, 2022 - Elsevier
Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …

The role of genetic factors in the development of acute respiratory viral infection COVID-19: predicting severe course and outcomes

MM Minashkin, NY Grigortsevich, AS Kamaeva… - Biomedicines, 2022 - mdpi.com
The aim of this study was to identify single nucleotide variants in genes associated with
susceptibility to or severe outcomes of COVID-19. A total of 319 genomic DNA samples from …

[HTML][HTML] Progress in salivary glands: Endocrine glands with immune functions

YF Shang, YY Shen, MC Zhang, MC Lv… - Frontiers in …, 2023 - frontiersin.org
The production and secretion of saliva is an essential function of the salivary glands. Saliva
is a complicated liquid with different functions, including moistening, digestion …

Severe COVID-19 ARDS treated by bronchoalveolar lavage with diluted exogenous pulmonary surfactant as salvage therapy: In pursuit of the holy grail?

B Ruaro, P Confalonieri, R Pozzan, S Tavano… - Journal of Clinical …, 2022 - mdpi.com
Background: Severe pneumonia caused by coronavirus disease 2019 (COVID-19) is
characterized by inflammatory lung injury, progressive parenchymal stiffening and …

Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactions

A Adli, M Rahimi, R Khodaie… - Journal of Medical …, 2022 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by a highly pathogenic emerging
virus, is called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Knowledge …