Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the
coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes …

The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …

Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

Abstract The Coronavirus Disease 2019 (COVID-19) pandemic is still spreading worldwide
over 2 years since its outbreak. The psychopathological implications in COVID-19 survivors …

During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with
the pathogenesis of other viral infections. Biological sex differences may manifest …

There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more
severe symptoms and higher mortality among men than among women,,,–. However …

Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …